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CVDs are the leading cause of death in patients with MASLD, whereas liver-related mortality is confined to patients with advanced fibrosis, with the risk rising exponentially as the fibrosis stage increases [6]

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A theoretical multi-target strategy might combine: NAD+ for ongoing metabolic support: sirtuin activation, DNA repair, mitochondrial maintenance, nutrient sensing recalibration Epitalon for periodic telomere maintenance: cyclic telomerase activation to preserve replicative capacity and delay senescence onset This combination would address at least seven hallmarks between the two interventions

Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBP

Effects of dietary valine:lysine ratio on the performance, amino acid composition of tissues and mRNA expression of genes involved in branched-chain amino acid metabolism of weaned piglets